Introduction: Permionics Leading in Biotech & Pharma Filtration
Permionics has spearheaded developments in downstream processing within the Biotech and Pharma industries, establishing itself as a leader in cutting-edge membrane technology. Following upstream processes, our MF ceramic system has become the preferred first unit operation for cell separation. This innovative solution provides a clarified broth product stream, facilitating easier and more efficient downstream processing for product enrichment and purification.
We offer customised ceramic membrane solutions tailored to diverse fermentation processes, adept at handling both intracellular and extracellular products derived from bacterial, fungal, or yeast fermentation. These advancements underscore Permionics’ commitment to delivering robust and versatile filtration systems that meet the evolving demands of modern biotechnological applications.
Introducing CERAFILT
The CERAFILT system exemplifies Permionics’ commitment to excellence in filtration. Designed as the preferred first unit operation post-upstream processes, CERAFILT ensures seamless cell separation and delivers a clarified broth product stream. This streamlining significantly enhances downstream product enrichment and purification processes across various industries.
Key Features of CERAFILT Ceramic Membrane System
– Advanced Membrane Design
CERAFILT’s ceramic membrane solutions are engineered to cater to diverse fermentation processes, addressing both intracellular and extracellular products. These membranes are particularly effective for bacterial, fungal, and yeast fermentation processes, ensuring optimal performance regardless of the complexity of the broth.
– Cell Density Flexibility
A hallmark of the CERAFILT system is its remarkable ability to handle cell densities ranging from 5% to 35% w/v. This flexibility makes it an indispensable tool for handling fermentation broths with varying complexities, offering unparalleled adaptability in different biotechnological applications.
Overcoming Challenges in Filtration
– Removal of Fines and Suspended Solids
The CERAFILT system is the ideal solution for removing fines, suspended particles, and colloidal matter that can hinder product quality. This technology is extensively utilised in industries such as agro-processing, herbal, food, and chemicals, delivering clarified product streams free from contaminants.
– Enhanced Product Stream Quality
When compared to alternative techniques, CERAFILT’s clarified product streams stand out for their superior quality. Free from turbidity and suspended particles, these streams enable more efficient downstream processes, ensuring better overall product yield.
Sterile Product Streams with CERAFILT
– Microbe Removal Capability
The advanced design of CERAFILT incorporates ceramic membranes with a 100-200 nm cutoff, effectively eliminating microbes from the product stream. This feature ensures sterile filtration and enhances product safety across various applications.
Ceramic Membrane Options for Various Applications
– MF and UF Ceramic Membranes
- MF Ceramic: Available in cutoffs of 25, 50, 100, 200, 500, 800, 1000, and 1200 nm.
- UF Ceramic: Available in cutoffs of 8, 15, 50, 150, and 300 kDa.
– Channel Diameter Options
CERAFILT offers diverse channel diameters (2, 4, 5, 6, and 8 mm) to accommodate feeds with different cell densities. This ensures optimal solids handling and enhances the filtration process’s efficiency.
CERAFILT’s Materials and Operating Parameters
– Durable Membrane Materials
Crafted from robust ceramic oxides such as ZrO₂, TiO₂, and Al₂O₃, CERAFILT membranes are built to withstand challenging conditions. They operate effectively across a broad pH range (0-14) and can handle a maximum Transmembrane Pressure (TMP) of 10 bars, ensuring durability and reliability.
– Flexible Operating Systems
The system is available with both automatic PLC-based and manual operating systems, featuring back-pulse provisions. This flexibility allows for efficient and customizable filtration processes tailored to specific needs.
Industries and Applications Utilising CERAFILT
– Wide Industry Applications
CERAFILT’s versatile design has found applications across a spectrum of industries, including enzymes, proteins, peptides, biofuels, herbals, antibiotics, carbohydrates, organic acids, biomass, nutraceuticals, and nanoparticles. Its ability to enhance product quality has made it a preferred choice for numerous commercial operations.
– Proven Performance
With a proven track record, CERAFILT has consistently delivered exceptional results in clarifying product streams and enhancing downstream processes. Its widespread adoption underscores its efficacy and reliability across various industrial sectors.
Pilot Plant Testing for Concept Validation
– Lab and On-Site Testing
Permionics offers pilot plant testing services to validate concepts before scaling up to commercial operations. These tests can be conducted both at Permionics’ lab and customer sites, ensuring tailored solutions and seamless integration into existing processes.
Conclusion
CERAFILT stands as a testament to Permionics’ innovative prowess, offering unparalleled capabilities in clarifying product streams, removing microbes, and handling diverse fermentation processes. Its advanced features and robust design make it a cornerstone of modern filtration technology. As a versatile and reliable solution, CERAFILT continues to revolutionise downstream processing across industries. By enhancing product quality and process efficiency, CERAFILT underscores Permionics’ dedication to driving excellence in filtration technology.
