Membrane Solution for Biotech / Bioprocesses

Permionics supports different biotech applications with our wide range of membranes that helps to purify products, enhance yield, reduce cost and provide selective separations. Our efficient processes are widely used for different applications involving separations, concentrations or purification of various biobased products made by fermentation or biocatalysis process. Our membranes can be used for all types of biomolecules i.e. fine chemicals, amino acids, vitamins, antibiotics, polymers, polysaccharides, antibodies and enzymes

Fermentation Broth

Recovery of product from the fermentation broth is an important step after any fermentation processes that is done using bacterial, yeast or fungal cells. We provide cross flow MF membrane system that is used for clarification of the broth and subsequently to wash out the remaining product from the cells (called diafiltration) achieving complete recovery of the product. We have experience and have supplied our membranes systems capable of handling cell densities ranging from 2 % to 40% (w/v) present in the fermentation broths.

Separations / Recovery

We offer solutions for recovery of macromolecules like proteins after the fermentation process. Our membranes can be used to separate the proteins from the product and other media components added during the fermentation process. The recovered protein can be recycled back into the fermentation process.
Some biotech applications use enzymes like cellulases, lipases, peroxidases etc. as a catalyst for the reactions, and recovery of these enzymes for reuse is important for improving economics. We offer membrane processes that can be used for the recovery of different enzymes.

Product Concentration

Permionics have pioneered the world’s first membrane for the Papain concentration application and we have also supplied systems for the concentration of Streptomycin.

  • We offer membrane processes that can be deployed for the concentration of the product from the dilute fermentation broth, UF permeates, biocatalysis reaction, natural products/extracts etc.
  • Our membranes can be effectively used for concentration of different organic acids like lactic acid, butyric acid, citric acid etc., obtained from the fermentation broth.
  • We also offer systems for the concentration of dilute extracts/products obtained from the natural products. We have a wide range of membranes that can be used for concentration of dilute products present in aqueous, acidic, alkaline and solvent based streams.
  • The streams obtained from chromatographic separations are dilute and depending on molecular weight of the product we can provide membrane system for concentration of these dilute streams.

CONCENTRATION AND SEPARATION are the two unit processes in which membranes play a vital role. Antibiotics, proteins, enzymes etc can be simultaneously concentrated and dashed/purified by selecting our suitable membranes.

Contact us for more details